1 animal models used in dentistry
Báo cáo hóa học: " Research Article An Effective Numerical Method and Its Utilization to Solution of Fractional Models Used in Bioengineering Applications" docx
... memory” principle can be used or without using “short memory” principle, we put v for all k in 2.22 Fractional-Order Models in Bioengineering Applications There are many fractional-order models, ... error in the solution Conclusions In this paper, we presented an effective numerical method and its application to solution of linear and nonlinear models of fractional order used in bioengineering ... T1 spin-lattice and T2 spin-spin The physical basis for T1 relaxation involves the protons Advances in Difference Equations losing their energy to the surrounding lattice, hence the name spin-lattice...
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Tài liệu Báo cáo khoa học: Animal models of amyloid-b-related pathologies in Alzheimer’s disease docx
... having sufficient power are therefore extremely important in minimizing the in uence of confounding factors arising from inherent problems associated with breeding APP transgenic mice and maintaining ... is now a renewed interest in studying APP processing in sporadic AD brain, and in understanding the mechanisms of Ab truncation and modification Most transgenic models produce mainly full-length ... pathology in female APParc mice is consistent with findings in Tg2576 mice [57] APP transgenic models harboring a presenilin, tau or a-synuclein transgene Presenilin transgenic mice were generated in...
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báo cáo hóa học: " Using animal models to determine the significance of complement activation in Alzheimer''''s disease" pptx
... numerous regulatory proteins including CD59, clusterin, vitronectin, C1-inhibitor, C4-binding protein, decay-activating factor, and Factor H, which inhibit different steps in the complement cascade All ... NFTs, and dystrophic neurites in the AD brain These findings are in agreement with in vitro studies indicating that Aβ and tau protein, the major components in SPs and NFTs, can fully activate human ... activation proteins in experimental animal models is a significant obstacle to determining the extent of complement activation in these models. ) In addition to neurons, complement proteins are synthesized...
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Báo cáo y học: "The value of animal models in predicting genetic susceptibility to complex diseases such as rheumatoid arthritis" ppsx
... Cia26 [61] Including interactions in the analysis has also allowed mapping of several other loci, including Cia41 and Cia42 in mouse and Cia26 in rats [60,68] Performing this type of study in humans ... approach the speed of mapping in humans while retaining the advantages of animal experiments Relevance of findings made in animal models It is sometimes argued that findings made in animals are not ... mapping with the power of mapping in animal models One such resource is heterogeneous stocks, in which several founder strains have been intercrossed for numerous generations, resulting in a fine...
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Báo cáo y học: " In vivo imaging approaches in animal models of rheumatoid arthritis" pot
... EC, Constantin G: Molecular mechanisms involved in lymphocyte recruitment in inflamed brain microvessels: critical roles for P-selectin glycoprotein ligand1 and heterotrimeric G(i)-linked receptors ... T-cell infiltrates in nonobese diabetic mice were readily detected in the pancreas [16] This suggests that the sensitivity is sufficient to be useful in tracking cells in inflammatory infiltrates ... considered in interpreting the results For example, in the cremaster muscle preparation, the abundant rolling leukocytes in the venules are due to P-selectin upregulation on endothelial cells in response...
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Báo cáo y học: " Gene therapy in animal models of rheumatoid arthritis: are we ready for the patients" pdf
... from local effects in the injected joint, it is becoming increasingly clear that local treatment also affects arthritis in nearby joints This is an intriguing and general finding, which may expand ... of proinflammatory cytokines, thereby reducing their circulating levels and abolishing a sensitizing effect on naïve joints A conflicting finding was the protection of the ipsilateral hind paw ... discriminate cytokine targeting and cell targeting as the two main gene therapeutic approaches to arthritis In cytokine targeting, the objective is to restore the (local) cytokine balance in arthritis...
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Báo cáo y học: "Cartilage-specific autoimmunity in animal models and clinical aspects in patients – focus on relapsing polychondritis" ppsx
... with matrilin-1, whereas the LEW.1A rat, carrying the same MHC alleles as the DA rat, was a high responder [3] In the murine models, preliminary data indicate that similar strains, carrying the ... swelling and pain, which mimic the symptoms of arthritis in RP patients In the majority of the rodent strains, however, this inflammation is erosive and symmetric This is in contrast to symptoms in ... Matrilin-1 Considering that cartilage tissue outside the diarthrodial joints is affected in RP patients, an immune response is likely to be induced against a cartilage protein expressed in the...
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Báo cáo y học: "The role of T cell interleukin-17 in conducting destructive arthritis: lessons from animal models" pps
... IL-1β protein in the synovium [41] Intriguingly, blocking of IL-1α/β with neutralizing antibodies had no effect on the IL-17-induced synovial inflammation and joint damage, implying an IL-1independent ... enhances tumor necrosis factor alpha-induced synthesis of interleukin 1, 6, and in skin and synovial fibroblasts: a possible role as a ‘fine-tuning cytokine’ in inflammation processes Arthritis Rheum ... interleukin 17 in inflammatory bowel disease Gut 2003, 52:65-70 Katz Y, Nadiv O, Beer Y: Interleukin-17 enhances tumor necrosis factor alpha-induced synthesis of interleukin 1, 6, and in skin and...
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Báo cáo y học: "Role of fibroblast growth factor 8 (FGF8) in animal models of osteoarthritis" doc
... developed using diaminobenzidine (brown) and counter stained with hematoxylin (blue) Very weak staining of FGF8 was observed in a few synovial cells, but not in other tissues in normal knee joints (d) ... anti-FGF8 antibody (Ab)) was intraperitoneally administered before the injection of FGF8 For the saline injection group (saline), 50 μl sterile saline was injected into the knee joint Synovial lavage ... administration of anti-FGF8 antibody significantly inhibited the increase in S-GAG in the joint by 42% (P = 0.0188; Figure 6) Discussion The present study provides new and interesting findings...
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Báo cáo y học: " Epitope spreading in animal models: array of hope in rheumatoid arthritis and multiple sclerosis" pot
... Venables reported in one previous study of collagen-induced arthritis [5], though other studies have found equal binding to both citrullinated and arginine-containing control peptides [6] In RA, the ... Tomooka B, Braschler KJ, Arend WP, Robinson WH, Holers VM: Antibodies against citrullinated proteins enhance tissue injury in experimental autoimmune arthritis J Clin Invest 2006, 116:961-973 Vossenaar ... named as inventors on this patent application References Kidd BA, Ho PP, Sharpe O, Zhao X, Tomooka BH, Kanter JL, Steinman L, Robinson WH: Epitope spreading to citrullinated antigens in mouse models...
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Báo cáo y học: "Colony variability under the spotlight in animal models of arthritis" pps
... proteoglycan-induced spondylitis and to determine expression patterns of a panel of relevant genes in a large number of distinct colonies of the susceptible mouse strain BALB/c Although induction ... any differences in incidence and severity, the sub-lines of BALB/c mice showed modest but significant differences in immune parameters such as cytokine and antibody responses and clinical scores ... PGIA model in different laboratories, and throws down the gauntlet as a challenge to research groups that use inbred strains of mice as models for other human diseases, particularly in cases when...
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Báo cáo khoa hoc:" On the use analysis of animal models in the of selection experiments" pdf
... larger than those obtained in the section setting, since more uncertainty is taken into account EVOLUTION OF GENETIC VARIANCE IN SELECTION EXPERIMENTS OVER SEVERAL GENERATIONS Moving from one cycle ... for the bias expected in breeding value prediction when an additive model is applied in a dominance situation In addition, the infinitesimal model cannot account for changes in gene frequency due ... of selection for food intake in mice In order to show the evolution of genetic variance, a two-step procedure of data splitting was implemented, first cumulating increasingly larger numbers of...
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Báo cáo y học: "The faunal drugstore: Animal-based remedies used in traditional medicines in Latin America" pptx
... catfish pain relief in injuries caused by the dorsal fin spine of a species of catfish [8,114,162] Genidens genidens (Cuvier, 1829) - catfish pain relief in injuries caused by the dorsal fin spine ... in popular medicine in Latin America (Continued) Rhinella marina (Linnaeus, 1758) - toad Scorpion sting, erysipelas Rhinella jimi (Stevaux, 2002)- toad Gastritis, cancer [87,152,158] [81] Rhinella ... swelling, herpes zoster, irritation when milk teeth are erupting, jaundice, inflammation, tumour, sore throat, infection, bronchits, injuries caused by the spines of the ‘arraia’, pain relief in injuries...
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Báo cáo y học: " Characterization of protein tyrosine phosphatase H1 knockout mice in animal models of local and systemic inflammation" docx
... [25,26] CARR injection in the hind paw of the mouse is one of the most commonly used models of inflammation and inflammatory pain and it has a biphasic profile [27] Recent studies pointed out important ... processing of other cytokines and cytokine receptors [32-35] Interestingly, PTPH1 is known to inhibit TACE expression and activity in vitro [36] We therefore analyzed cytokines plasma levels in carrageenan-treated ... Journal of Inflammation 2010, 7:16 http://www.journal-inflammation.com/content/7/1/16 and activates both MyD88-dependent and independent (TRIF-dependent-TIR-domain-containing adapterinducing interferon-β)...
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Báo cáo y học: "Anti-inflammatory effects of Radix Gentianae Macrophyllae (Qinjiao), Rhizoma Coptidis (Huanglian) and Citri Unshiu Pericarpium (Wenzhou migan) in animal models" doc
... anti-inflammatory effects in various experimental models The primary ingredient in Radix Gentianae Macrophyllae is gentiopicroside which was shown to have anti-inflammatory effects in a murine ... Thirty minutes after the administration, each mouse was intravenously injected (at the tail) with 0.1 ml of 4% Evans blue (10 μl/g of body weight, Sigma, USA) in saline Fifteen minutes after the intravenous ... and combined to form KHU14 according to their anti-inflammatory effects and traditional usage in Chinese medicine and their major active ingredients KHU14 was evaluated for its anti-inflammatory...
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Anti inflammatory effects of inhibitors of the tyrosine kinase signaling cascade in animal models of asthma
... proteins include protein serine-threonine kinases (Akt and phosphoinositidedependent kinase (PDK1)), protein tyrosine kinases (Btk and Tec family), exchange factor for GTP-binding proteins (Grp1 ... protein (MBP), eosinophil cationic protein (ECP), eosinophil peroxidase, and eosinophil-derived neurotoxin, as well as cytokines and chemokines (Giembycz and Lindsay, 1999) Eosinopoiesis begins in ... proliferation increasing cholinergic-induced contraction inducing type I collagen synthesis potently inducing eotaxin expression altering mucocilliary differentiation resulting in goblet cell metaplasia...
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Anti inflammatory effects of inhibitors of the tyrosine kinase signaling cascade in animal models of asthma
... fluid eosinophilia in sensitized guinea pigs 4.7 85 Effects of genistein on OVA-induced AHR to inhaled methacholine in sensitized guinea pigs 4.12 84 OVA-induced AHR to inhaled methacholine in sensitized ... trachea in guinea pigs 4.9E-H 80 Effects of genistein on EPO activity in cell-free BAL fluid in guinea pigs 4.9A-D 79 Effects of genistein or daidzein on OVA-induced BAL fluid eosinophilia in guinea ... GRB2-associated binding protein granulocyte-macrophage colony-stimulating factor G-protein-coupled receptor intracellular adhesion molecule immunoglobulin interleukin inositol 1,4,5-triphosphate insulin receptor...
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The function of anxiety fear related genes in animal models 3
... conditioning after i.h injection Mice were injected with 50ng CCK4 30min before training Context- and tone-dependent fear conditioning were determined 24hr later Figures 201 Figure 7-12 The i.s injection ... preprocholecystokinin The signal peptide consists of residues 20 to The amino terminal flanking peptide consists of residues to 25 The largest characterized form from brain and intestine, CCK-58, ... CRF-R Figures 176 Figure 1-6 Interactions between mammalian corticotropin releasing factor (CRF)like peptides, their receptors and the CRF binding protein (CRF-BP) Binding to the CRF-BP or activation...
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The function of anxiety fear related genes in animal models 2
... administration can be explained by the fact that in some studies, different CCK fragments have been infused in different brain areas in order to delineate the anatomical substrate of CCK-inducing ... effects in learning were not observed when astressin or antisauvagine-30 was injected into the dorsal hippocampus Injection of CRF after the training into the dorsal hippocampus or the lateral intermediate ... an anxiolytic effect in a variety of tests on animal models, including punished drinking tests, social interaction tests and maze tests in rats and marble burying tests in mice It does not have...
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The function of anxiety fear related genes in animal models
... BZ benzodiazepine cAMP cyclic adenosine monophosphate CCK cholecystokinin CNS central nervous system CORT corticosterone CRF corticotropin-releasing factor CRF-BP CRF-binding protein CS conditioned ... (Glu11,16)-astressin I.c.v injection of CCK4 before training, but not after training, reduced the freezing behavior of mice on both context- and tone-dependent fear conditioning This impairment ... (Glu11,16)-astressin 15 minutes before the application of CCK4, while injection of (Glu11,16)-astressin alone did not exhibit any significant effect The finding that (Glu11,16)-astressin could block...
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